Mitochondrial & Cellular Health
NAD+, Sirtuins, and Cellular Repair Pathways
Why NAD+ gets attention
NAD+ is involved in energy metabolism, DNA repair, mitochondrial function, and signaling pathways linked to aging biology. Levels may decline with age and metabolic stress.
Sirtuins in context
Sirtuins are enzymes that depend on NAD+ and are involved in stress responses, metabolism, and cellular maintenance. This does not mean more NAD+ automatically means longer life in humans.
The evidence gap
NAD+ precursors are being studied, but longevity claims often exceed the human evidence. Safety, dose, medical context, and goals matter.
Clinical approach
Before supplementing, address sleep, exercise, alcohol, metabolic health, inflammation, and nutrient adequacy. Then consider targeted support if appropriate.
Practical takeaways
- Longevity medicine should be personalized, measured, and realistic.
- The strongest foundations are usually sleep, movement, metabolic health, nutrition, stress physiology, and reducing avoidable risk.
- Biomarkers and devices are most useful when they answer a clear question and lead to a safe action.
- Supplements, hormones, and advanced testing should be individualized and clinically supervised.
How SANAVITA Health approaches this
SANAVITA Health approaches longevity through a physician-led, whole-person lens. We focus on education, biomarkers, metabolic resilience, hormonal context, mitochondrial and cellular health, cognitive protection, and sustainable habits that fit the patient’s life.
Research references
- Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. 2021 https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/
- López-Otín C, et al. Hallmarks of aging: An expanding universe. Cell. 2023 https://pubmed.ncbi.nlm.nih.gov/36599349/
- Sun N, Youle RJ, Finkel T. The Mitochondrial Basis of Aging. Molecular Cell. 2016 https://pmc.ncbi.nlm.nih.gov/articles/PMC4762029/
- Justice JN, et al. A framework for selection of blood-based biomarkers for geroscience-guided clinical trials. 2018 https://pmc.ncbi.nlm.nih.gov/articles/PMC6336355/
