Immune Function & Inflammation
Natural Killer Cells: What You Can Do to Support Immune Surveillance

What NK cells do
Natural killer cells are immune cells involved in surveillance against virally infected and abnormal cells. They are part of innate immunity and interact with many other immune pathways involved in cancer biology (Deng et al., Biomedicines, 2021).
What patients can control
Lifestyle factors such as sleep, physical activity, stress physiology, nutrition status, and inflammation may influence immune function. However, no lifestyle practice guarantees NK-cell activity against cancer.
Practical support
Foundational strategies include regular sleep timing, protein adequacy, resistance and aerobic exercise when safe, infection prevention, adequate vitamin D status when clinically appropriate, and reducing avoidable alcohol or smoking exposures.
Avoid overclaiming
Be cautious with products marketed to “activate NK cells” without human oncology outcomes. Immune support must be reviewed in context of immunotherapy, transplant history, autoimmune disease, and medications.
Practical takeaways
- NK cells are a real and important part of immune surveillance — but no supplement is proven to improve cancer outcomes through them.
- Sleep, physical activity, protein adequacy and stress regulation are the supports with actual evidence behind them.
- Be sceptical of any product marketed as raising NK cell activity to fight cancer.
- Laboratory NK measurements are not a validated way to guide treatment decisions.
How SANAVITA Health approaches this
SANAVITA Health provides physician-led integrative oncology education and support with a focus on clarity, safety, whole-person care, and collaboration. The goal is to help patients understand their options, reduce avoidable risk, and build a supportive plan that fits their diagnosis, treatment phase, values, and care team recommendations.
Research references
- Deng X, et al. Immunosurveillance of Cancer and Viral Infections with Natural Killer Cells. Biomedicines. 2021 https://www.mdpi.com/2227-9059/9/5/557
- Ligibel JA, et al. Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline. Journal of Clinical Oncology. 2022 https://ascopubs.org/doi/10.1200/JCO.22.00687
- Kang X, et al. Modulating gut microbiome in cancer immunotherapy. Cell Reports Medicine. 2024 https://pmc.ncbi.nlm.nih.gov/articles/PMC11031381/
- Greten FR, Grivennikov SI. Inflammation and Cancer: Triggers, Mechanisms and Consequences. Immunity. 2019 https://pmc.ncbi.nlm.nih.gov/articles/PMC6831096/


